RNA Chemist - Indianapolis, IN 1

Company Overview:

ATL, A Bureau Veritas Company is a professional services organization with an ever-broadening service portfolio to support FDA-regulated products and companies worldwide. Providing scientific, engineering, and regulatory laboratory services, we seamlessly leverage our expertise within the consumer product goods, pharmaceutical, and medical device industries. 

Headquartered in Cincinnati, Ohio, we are a highly profitable and nimble entrepreneurial organization comprised of nearly 500 experts who work throughout the United States. Anchored by the mission to add value to our clients throughout all stages of the product life cycle, we are the most desired business partner for our Fortune 500 clients.
 
Perks & Benefits at ATL:

• Medical, Vision, and Dental Insurance
• Short-Term and Long-Term Disability paid by Employer
• 401(k) Retirement Plan with Employer Contribution
• Paid Time Off
• Employee Assistance Plan
• Employee Discount Program
• Wellness Program
• Career Mobility & Ongoing Development

Position Summary:

The Chemist is responsible for the synthesis and downstream processing of oligo synthesis using various analytical techniques.  AKTA, LC-MS, UPLC, LTQ, QDA analytical instruments are used.

Hours worked: Typically, M-F, forty hours per week.  However, must be flexible to meet the needs of the department and complete other projects as assigned.

What You’ll Do:

• Synthesis of oligonucleotides on AKTA oligo pilot for solid-phase oligonucleotide synthesis
• Downstream processing of large-scale oligo synthesis: cleavage, deprotection, purification and desalt
• Bioconjugation of single strand oligonucleotides
• Use of general laboratory equipment including but not limited to pipettors, centrifuges, incubators, biological safety cabinets and balances
• Instrumentation for methods and techniques described include AKTA, LC-MS, UPLC, LTQ, QDA, Nanodrop, etc.
• Data analysis and troubleshooting
• Work closely with members of the RNAi scale up chemistry team to understand and validate requirements for synthesis scaleup and downstream processing
• Lab experience with solution preparation, separation, quantification, synthesis methodologies for DNA/RNA, proteins, oligonucleotides, etc.
• Software includes instrument-specific for capturing and analyzing data, Microsoft Office (Word, Excel, PowerPoint, Outlook, Teams/Sharepoint, etc), LIMS, electronic laboratory notebooks, etc.
• Detailed record keeping of daily experiments in ELNs
• General Lab Maintenance
• Follow the guidelines set forth with clients and Company Quality, Health, Safety, Security and Environmental policies and procedures.
• Comply with clients’ and Company management systems in accordance with appropriate regulatory agencies.
• Perform other essential tasks projects and responsibilities as required.
• Other duties as defined by Manager, department needs and workload

What You'll Need:

• Experience, troubleshooting, and optimizing synthetic protocols on AKTA oligo pilot for solid-phase oligonucleotide synthesis
• Strong laboratory skills and experience with analytical instrumentation such as AKTA, Agilent LC-MS and UPLC, Vanquish LTQ, Water’s QDA, etc.
• Experience in developing new chromatographic methods (IEX/RP-HPLC, SPE, LC-MS).
• Strong organizational skills
• Strong written and oral communication skills
• Confident, execution-focused, and team oriented with a desire to thrive in a fast-paced growing environment
• Written and verbal communication skills including the ability to communicate effectively in a group setting, with colleagues and clients
• Ability to perform multiple tasks
• Ability to organize and prioritize workload to meet or exceed deadlines
• Individual and Team work ethic
• Proficiency with Windows, Word & Excel
• Attention to detail
• Positive attitude, self-motivated, high level of engagement
• Adheres to company values

Educational Requirements:

• Degree requirement: Bachelor's Degree in Chemistry, Biochemistry, or closely related field
• Minimum of one (1) year of experience with oligonucleotide chemistry

An equivalent combination of education and experience may be accepted in lieu of above.

AT ATL, we are an Equal Opportunity Employer and take pride in a diverse environment. We do not discriminate in recruitment, hiring, training, promotion, or other employment practices for reasons of race, color, religion, gender, sexual orientation, national origin, age, marital or veteran status, medical condition or disability, or any other legally protected status. ATL strongly supports diversity in the workplace.